“The FSGS Factor”: Enrichment and: in Vivo: Effect of Activity from Focal Segmental Glomerulosclerosis Plasma
M Sharma, R Sharma, ET McCarthy… - Journal of the American …, 1999 - journals.lww.com
A circulating causative factor has been postulated in focal segmental glomerulosclerosis
(FSGS). It has been shown that serum or plasma from some FSGS increases glomerular
albumin permeability (P alb) in vitro. P alb greater than 0.5 (ie, FS activity) is associated with
recurrence after transplantation. Specimens from 15 FSGS patients were studied to
document the presence of a permeability factor, to isolate this factor, to characterize its
biochemical properties, and to show its effect in vivo. Total lipids were extracted by …
(FSGS). It has been shown that serum or plasma from some FSGS increases glomerular
albumin permeability (P alb) in vitro. P alb greater than 0.5 (ie, FS activity) is associated with
recurrence after transplantation. Specimens from 15 FSGS patients were studied to
document the presence of a permeability factor, to isolate this factor, to characterize its
biochemical properties, and to show its effect in vivo. Total lipids were extracted by …
