[HTML][HTML] Differential MAPK pathways utilized for HGF-and EGF-dependent renal epithelial morphogenesis
A Karihaloo, DA O'Rourke, C Nickel, K Spokes… - Journal of Biological …, 2001 - ASBMB
Cells derived from the inner medullary collecting duct undergo in vitro branching
tubulogenesis to both the c-met receptor ligand hepatocyte growth factor (HGF) as well as
epidermal growth factor (EGF) receptor ligands. In contrast, many other cultured renal
epithelial cells respond in this manner only to HGF, suggesting that these two receptors may
use independent signaling pathways during morphogenesis. We have therefore compared
the signaling pathways for mIMCD-3 cell morphogenesis in response to EGF and HGF …
tubulogenesis to both the c-met receptor ligand hepatocyte growth factor (HGF) as well as
epidermal growth factor (EGF) receptor ligands. In contrast, many other cultured renal
epithelial cells respond in this manner only to HGF, suggesting that these two receptors may
use independent signaling pathways during morphogenesis. We have therefore compared
the signaling pathways for mIMCD-3 cell morphogenesis in response to EGF and HGF …