Dichloromethane potentiation of carbon tetrachloride hepatotoxicity in rats
YC Kim - Fundamental and Applied Toxicology, 1997 - Elsevier
Concomitant treatment of rats with a nonhepatotoxic dose of dichloromethane (6 mmol/kg,
ip) significantly potentiated the hepatotoxicity of carbon tetrachloride (2 mmol/kg, ip). Toxicity
was determined by increases in serum sorbitol dehydrogenase and alanine
aminotransferase activities measured 24 hr following the treatments. Dichloromethane did
not affect the lipid peroxidation induced by carbon tetrachloride as determined by
conjugated diene formation in hepatic microsomal lipids. The covalent binding of [14C] …
ip) significantly potentiated the hepatotoxicity of carbon tetrachloride (2 mmol/kg, ip). Toxicity
was determined by increases in serum sorbitol dehydrogenase and alanine
aminotransferase activities measured 24 hr following the treatments. Dichloromethane did
not affect the lipid peroxidation induced by carbon tetrachloride as determined by
conjugated diene formation in hepatic microsomal lipids. The covalent binding of [14C] …
