[HTML][HTML] Contractile activity stimulates the c-Jun NH2-terminal kinase pathway in rat skeletal muscle
D Aronson, SD Dufresne, LJ Goodyear - Journal of Biological Chemistry, 1997 - ASBMB
Contractile activity plays a critical role in the regulation of gene transcription in skeletal
muscle, which in turn determines muscle functional capabilities. However, little is known
about the molecular signaling mechanisms that convert contractile activity into gene
regulatory responses in skeletal muscle. In the current study we determined the effects of
contractile activity in vivo on the c-Jun NH 2-terminal kinase (JNK) pathway, a signaling
cascade that has been implicated in the regulation of transcription. Electrical stimulation of …
muscle, which in turn determines muscle functional capabilities. However, little is known
about the molecular signaling mechanisms that convert contractile activity into gene
regulatory responses in skeletal muscle. In the current study we determined the effects of
contractile activity in vivo on the c-Jun NH 2-terminal kinase (JNK) pathway, a signaling
cascade that has been implicated in the regulation of transcription. Electrical stimulation of …