Restraint stress-induced immunosuppression by inhibiting leukocyte migration and Th1 cytokine expression during the intraperitoneal infection of Listeria …

D Zhang, K Kishihara, B Wang, K Mizobe… - Journal of …, 1998 - Elsevier
In this study, a murine model of Listeria monocytogenes infection was used to investigate
effects of restraint stress (RST) on host defense. We observed that the L. monocytogenes
infection as well as RST induced an elevation of endogenous corticosterone (CORT) levels
and RST synergistically enhanced endogenous CORT levels during the listerial infection.
RST suppressed the migration of leukocytes including macrophages, neutrophils, NK cells
and lymphocytes into the peritoneal cavities after the intraperitoneal inoculation of L …