Low permeabilities of apical membranes of barrier epithelia: what makes watertight membranes watertight?
ML Zeidel - American Journal of Physiology-Renal …, 1996 - journals.physiology.org
American Journal of Physiology-Renal Physiology, 1996•journals.physiology.org
Several epithelia, including those of collecting duct (in the absence of antidiuretic hormone),
thick ascending limb of Henle, and mammalian bladder exhibit extremely low permeabilities
for water, small nonelectrolytes like urea, and protons. This brief review describes how
apical membrane structure might account for these low permeabilities by incorporating
recent biophysical and molecular modeling results.
thick ascending limb of Henle, and mammalian bladder exhibit extremely low permeabilities
for water, small nonelectrolytes like urea, and protons. This brief review describes how
apical membrane structure might account for these low permeabilities by incorporating
recent biophysical and molecular modeling results.
Several epithelia, including those of collecting duct (in the absence of antidiuretic hormone), thick ascending limb of Henle, and mammalian bladder exhibit extremely low permeabilities for water, small nonelectrolytes like urea, and protons. This brief review describes how apical membrane structure might account for these low permeabilities by incorporating recent biophysical and molecular modeling results.
American Physiological Society