Inhibition of growth of colon 38 adenocarcinoma by vinblastine and colchicine: evidence for a vascular mechanism
BC Baguley, KM Holdaway, LL Thomsen… - European Journal of …, 1991 - Elsevier
Vinblastine or colchicine, administered intraperitoneally to B6D2F 1 mice with advanced
subcutaneous colon 38 tumours, induced substantial tumour growth delays with progressive
development of haemorrhagic necrosis beginning within 8 hours of treatment. Two multidrug-
resistant P388 leukaemia sublines, refractory to vinblastine and vincristine when grown as
intraperitoneal ascites, were sensitive to necrosis induction when grown as subcutaneous
tumours. Vascular labelling with two fluorescent markers indicated that vincristine …
subcutaneous colon 38 tumours, induced substantial tumour growth delays with progressive
development of haemorrhagic necrosis beginning within 8 hours of treatment. Two multidrug-
resistant P388 leukaemia sublines, refractory to vinblastine and vincristine when grown as
intraperitoneal ascites, were sensitive to necrosis induction when grown as subcutaneous
tumours. Vascular labelling with two fluorescent markers indicated that vincristine …
