Oxidatively fragmented phospholipids as inflammatory mediators: the dark side of polyunsaturated lipids
GA Zimmerman, SM Prescott, TM McIntyre - The Journal of nutrition, 1995 - Elsevier
Phospholipids containing a polyunsaturated fatty acyl residue at the sn-2 position are
common constituents of cellular membranes and lipoprotein particles. Just as free
polyunsaturated fatty acids can be oxidized, derivatized, and fragmented, phospholipid acyl
residues are also subject to similar oxidative attack. Oxidative modification and/or
fragmentation of phosphatidylcholines generate potent inflammatory mediators that mimic
the biologic action of platelet-activating factor (PAF). The oxidatively fragmented …
common constituents of cellular membranes and lipoprotein particles. Just as free
polyunsaturated fatty acids can be oxidized, derivatized, and fragmented, phospholipid acyl
residues are also subject to similar oxidative attack. Oxidative modification and/or
fragmentation of phosphatidylcholines generate potent inflammatory mediators that mimic
the biologic action of platelet-activating factor (PAF). The oxidatively fragmented …
