[HTML][HTML] Induction of Apoptosis by Pyrrolidinedithiocarbamate and N-Acetylcysteine in Vascular Smooth Muscle Cells (∗)
Pyrrolidinedithiocarbamate (PDTC) and N-acetylcysteine (NAC) have been used as
antioxidants to prevent apoptosis in lymphocytes, neurons, and vascular endothelial cells.
We report here that PDTC and NAC induce apoptosis in rat and human smooth muscle cells.
In rat aortic smooth muscle cells, PDTC induced cell shrinkage, chromatin condensation,
and DNA strand breaks consistent with apoptosis. In addition, overexpression of Bcl-2
suppressed vascular smooth muscle cell death caused by PDTC and NAC. The viability of …
antioxidants to prevent apoptosis in lymphocytes, neurons, and vascular endothelial cells.
We report here that PDTC and NAC induce apoptosis in rat and human smooth muscle cells.
In rat aortic smooth muscle cells, PDTC induced cell shrinkage, chromatin condensation,
and DNA strand breaks consistent with apoptosis. In addition, overexpression of Bcl-2
suppressed vascular smooth muscle cell death caused by PDTC and NAC. The viability of …